Bhatia KP1, Münchau A1, Thompson PD1, Houser M1, Chauhan VS1, Hutchinson M2Shapira AHV1,3, Marsden CD1

 

J Neurol Neurosurg Psychiatry. 1999 Jul;67(1):90-3.

 

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ABSTRACT:


Three patients are reported on who developed transient generalised weakness after receiving therapeutic doses of botulinum toxin for cervical dystonia (one case) and symptomatic hemidystonia (two cases) respectively. Clinical and electrophysiological findings were in keeping with mild botulism. All patients had received previous botulinum toxin injections without side effects and one patient continued injections without recurrence of generalised weakness. The cause is most likely presynaptic inhibition due to systemic spread of the toxin. Patients with symptomatic dystonia may be more likely to have this side eVect and botulinum toxin injections in these patients should be carried out cautiously.


 

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